RNA viruses: genome structure and evolution
نویسندگان
چکیده
منابع مشابه
Episodic evolution of RNA viruses.
The molecular clock and the neutral allele theory have been intimately intertwined since both were conceived in the 1960s (1-3). The molecular clock embodies the observation that rates of molecular evolution are nearly constant; the neutral allele theory provides a mechanistic explanation for the constancy. Like most relationships, that between the neutral theory and the molecular clock has had...
متن کاملRNA viruses – evolution in action
remain unreconciled with frequent anthropomorphic interpretations of their own work. To others, the theory of evolution is additionally difficult to comprehend and win universal acceptance because it operates so slowly and imponderably on the most important objects of study, ourselves and the primates from whom we descend. With RNA viruses, however, we have the opportunity to observe evolution ...
متن کاملBioinformatic and physical characterizations of genome-scale ordered RNA structure in mammalian RNA viruses.
By the analysis of thermodynamic RNA secondary structure predictions, we previously obtained evidence for evolutionarily conserved large-scale ordering of RNA virus genomes (P. Simmonds, A. Tuplin, and D. J. Evans, RNA 10:1337-1351, 2004). Genome-scale ordered RNA structure (GORS) was widely distributed in many animal and plant viruses, much greater in extent than RNA structures required for vi...
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This impressive monograph by Edward Holmes opens with a quotation from La Peste, by Albert Camus: “Everyone knows that pestilences have a way of recurring in the world; yet somehow we fi nd it hard to believe in ones that crash down on our heads from a blue sky.” This apt quotation might lead the reader to believe that the evolution and emergence of RNA viruses in causing new diseases would be ...
متن کاملQuasispecies structure and persistence of RNA viruses.
Viral quasispecies are closely related (but nonidentical) mutant and recombinant viral genomes subjected to continuous genetic variation, competition, and selection. Quasispecies structure and dynamics of replicating RNA enable virus populations to persist in their hosts and cause disease. We review mechanisms of viral persistence in cells, organisms, and populations of organisms and suggest th...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1992
ISSN: 0960-9822
DOI: 10.1016/0960-9822(92)90425-a